Dendritic cell immunotherapy: clinical outcomes
نویسندگان
چکیده
منابع مشابه
Dendritic cell immunotherapy: clinical outcomes
The use of tumour-associated antigens for cancer immunotherapy studies is exacerbated by tolerance to these self-antigens. Tolerance may be broken by using ex vivo monocyte-derived dendritic cells (DCs) pulsed with self-antigens. Targeting tumour-associated antigens directly to DCs in vivo is an alternative and simpler strategy. The identification of cell surface receptors on DCs, and targeting...
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Background: Bacterial DNA has immunostimulatory effects on different types of immune cells such as dendritic cells (DCs). Application of DCs as a cellular adjuvant represents a promising approach in the immunotherapy of infectious disease and cancers. Objectives: To investigate the effect of tumor antigen pulsed DCs in the presence of CpG-1826 in treatment of a murine model of cancer. Methods: ...
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Cancer immunotherapy has gained a lot of interest over the past few years due to the success of immune checkpoint inhibitors in treating cancer (1, 2). Immune checkpoint inhibitors, such as monoclonal antibodies against cytotoxic T-lymphocyte–associated antigen 4 (CTLA-4) and programmed death 1 (PD-1), have been shown to increase survival of patients with advanced cancers (1, 2). These in...
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Dendritic cell have been recognized as most potent antigen presenting cells that capable of activating T cells against tumor antigen. Dendritic cells were first discovered by Steinman RM & Cohn ZA et al. [1]. He was awarded Nobel Prize in medicine in 2011 for discover of these novel cells. Expression of costimulatory molecule and ability to generate strong immune response differentiate it from ...
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ژورنال
عنوان ژورنال: Clinical & Translational Immunology
سال: 2014
ISSN: 2050-0068
DOI: 10.1038/cti.2014.14